The Science of Canine Healthy Aging
CGI approaches canine aging as a connected biological system involving resilience, metabolism, immune function, body composition, mobility, cognition, structural integrity, and cellular maintenance.
Why CGI Uses a Systems View of Aging
Canine aging involves progressive changes in physiological resilience, metabolism, immune function, body composition, mobility, cognition, structural integrity, and cellular maintenance.
These changes are connected; decline in one system may influence several others.
For example, microbiome changes may affect microbial metabolites and immune signaling; oxidative stress may influence cellular maintenance; reduced activity may affect muscle condition, metabolism, and quality of life.
CGI therefore treats aging as a biological system rather than a list of isolated symptoms.
Connected Biology
CGI examines relationships across physiological, metabolic, immune, structural, functional, and cellular systems.
Evidence Interpretation
Findings are organized and interpreted according to scientific strength, study design, context, and limitations.
Geronutrition
Nutrition is considered within the biology of aging, resilience, maintenance, and support of healthspan-related functions.
Five Core Areas of CGI Science
The CGI Science section is organized around five complementary areas, each with a distinct role in understanding canine healthy aging.
Foundations
Established biological knowledge and reference material.
Explore Foundations →Conceptual Framework
CGI model for organizing aging and geronutrition evidence.
Explore Framework →
Interpretation Principles
Rules for distinguishing credible findings from overinterpretation.
View Principles →Biological Domains
Six primary areas through which CGI evaluates healthspan.
Explore Domains →Ingredient Science
Scientific assessment of nutritional intervention categories.
Explore Ingredient Science →Examples of Interconnected Aging Biology
CGI uses a systems perspective because age-related changes can interact across multiple biological and functional areas.
Microbiome
Microbiome changes may influence microbial metabolites and immune signaling.
Oxidative Stress
Oxidative stress may influence cellular maintenance and biological resilience.
Activity
Reduced activity may affect muscle condition, metabolism, and broader functional capacity.
Quality of Life
Functional decline in one area may influence overall quality-of-life outcomes.
From Foundational Biology to Responsible Evidence Interpretation
Explore the CGI framework, scientific foundations, interpretation principles, biological domains, and ingredient-science resources.